HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 4-methoxypyridine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methyl 4-Chloropicolinate | HCID 820890 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Product | Methyl 4-methoxypyridine-2-carboxylate | HCID 1519345 | — |
Reaction Steps
A mixture of methyl 4-chloropyridine-2-carboxylate (3.7 g), sodium metal (0.5 g) and methanol (100 ml) was stirred and heated to reflux for 8 hours. The mixture was evaporated and the residue was partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated to give methyl 4-methoxypyridine-2-carboxylate (3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821246 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-20b68bca3eea4b289fb28d8fe1e448c8 |
| Source note | uspto-grants-1998_10 |