反应详情

A mixture of methyl 4-chloropyridine-2-carboxylate (3.7 g), sodium metal (0.5 g) and methanol (100 ml) was stirred and heated to reflux for 8 hours. The mixture was evaporated and the residue was partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated to give methyl 4-methoxypyridine-2-carboxylate (3 g).

1. temperatureheated
2. temperatureto reflux for 8 hours
3. customThe mixture was evaporated
4. customthe residue was partitioned between ethyl acetate and water
5. dry with materialThe organic phase was dried (MgSO4)
6. customevaporated