Thionyl Chloride → 6-Acetoxy-4-chloroquinazoline hydrochloride

HRID 399482Notes

Reaction equation

[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][NH:9][C:8]2=O)(=[O:3])[CH3:2].S(Cl)([Cl:18])=O>>[ClH:18].[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][N:9]=[C:8]2[Cl:18])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 1355842204-Oxo-1,4-dihydroquinazolin-6-yl acetate

Product 1

HCID 189676236-Acetoxy-4-chloroquinazoline hydrochloride

Procedure

Using an analogous procedure to that described in the first paragraph of the portion of Example 1 which is concerned with the preparation of starting materials, 6-acetoxyquinazolin-4-one was reacted with thionyl chloride to give 6-acetoxy-4-chloroquinazoline hydrochloride which was used without further purification.

Sources & evidence

ORD record: ord-b47cba7530ca4415aa319bcf55257638
Source dataset: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05821246

Reaction notes

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