6-Acetoxy-4-chloroquinazoline hydrochloride → 6-Acetoxy-4-[3-chloro-4-(2-thienylcarbonyl)anilino]quinazoline hydrochloride salt

HRID 399483Notes

Reaction equation

HRID 399483 reaction equation
Cl.[C:2]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][N:10]=[C:9]2[Cl:16])(=[O:4])[CH3:3].[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[C:22]([C:24]1[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][C:25]=1[Cl:31])=[O:23]>>[ClH:16].[C:2]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][N:10]=[C:9]2[NH:30][C:27]1[CH:28]=[CH:29][C:24]([C:22]([C:18]2[S:17][CH:21]=[CH:20][CH:19]=2)=[O:23])=[C:25]([Cl:31])[CH:26]=1)(=[O:4])[CH3:3]

Participants

3

Reactant 2

HCID 189676236-Acetoxy-4-chloroquinazoline hydrochlorideHCID 539466203-Chloro-4-(2-thenoyl)aniline

Product 1

HCID 189676656-Acetoxy-4-[3-chloro-4-(2-thienylcarbonyl)anilino]quinazoline hydrochloride saltYield 77%

Procedure

Using an analogous procedure to that described in Example 1, 6-acetoxy-4-chloroquinazoline hydrochloride was reacted with 4-amino-2-chlorophenyl 2-thienyl ketone to give 6-acetoxy-4-[3-chloro-4-(2-thienylcarbonyl)anilino]quinazoline hydrochloride salt in 77% yield, m.p. >250° C.;

Sources & evidence

ORD record
ord-ae351f350435473497db323e322c36eb
Source dataset
uspto-grants-1998_10
Patent number
US05821246

Reaction notes

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