HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Acetoxy-4-chloroquinazoline hydrochloride → 6-Acetoxy-4-[3-chloro-4-(2-thienylcarbonyl)anilino]quinazoline hydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Acetoxy-4-chloroquinazoline hydrochloride | HCID 18967623 | — |
| Reactant | 3-Chloro-4-(2-thenoyl)aniline | HCID 53946620 | — |
| Product | 6-Acetoxy-4-[3-chloro-4-(2-thienylcarbonyl)anilino]quinazoline hydrochloride salt | HCID 18967665 | 77% |
Reaction Steps
Using an analogous procedure to that described in Example 1, 6-acetoxy-4-chloroquinazoline hydrochloride was reacted with 4-amino-2-chlorophenyl 2-thienyl ketone to give 6-acetoxy-4-[3-chloro-4-(2-thienylcarbonyl)anilino]quinazoline hydrochloride salt in 77% yield, m.p. >250° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821246 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-ae351f350435473497db323e322c36eb |
| Source note | uspto-grants-1998_10 |