6-Acetoxy-4-chloroquinazoline hydrochloride → 6-Acetoxy-4-[3-fluoro-4-(1-methylimidazol-2-ylthio)anilino]quinazoline dihydrochloride salt
Reaction equation
[ClH:1].[C:2]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][N:10]=[C:9]2[Cl:16])(=[O:4])[CH3:3].[CH3:17][N:18]1[CH:22]=[CH:21][N:20]=[C:19]1[S:23][C:24]1[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][C:25]=1[F:31]>>[ClH:16].[ClH:1].[C:2]([O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][N:10]=[C:9]2[NH:30][C:27]1[CH:28]=[CH:29][C:24]([S:23][C:19]2[N:18]([CH3:17])[CH:22]=[CH:21][N:20]=2)=[C:25]([F:31])[CH:26]=1)(=[O:4])[CH3:3]Participants
3
Procedure
Using an analogous procedure to that described in Example 1, 6-acetoxy-4-chloroquinazoline hydrochloride was reacted with 4-amino-2-fluorophenyl 1-methylimidazol-2-yl sulphide to give 6-acetoxy-4-[3-fluoro-4-(1-methylimidazol-2-ylthio)anilino]quinazoline dihydrochloride salt in 58% yield, m.p. 245-248 (decomposes);
Sources & evidence
- ORD record
- ord-472a0a9ba0b143d4a453915915caf4c3
- Source dataset
- uspto-grants-1998_10
- Patent number
- US05821246
Reaction notes
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