HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Acetoxy-4-chloroquinazoline hydrochloride → 6-Acetoxy-4-[3-fluoro-4-(1-methylimidazol-2-ylthio)anilino]quinazoline dihydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Acetoxy-4-chloroquinazoline hydrochloride | HCID 18967623 | — |
| Reactant | 4-Amino-2-fluorophenyl 1-methylimidazol-2-yl sulphide | HCID 28972767 | — |
| Product | 6-Acetoxy-4-[3-fluoro-4-(1-methylimidazol-2-ylthio)anilino]quinazoline dihydrochloride salt | HCID 18967681 | 58% |
Reaction Steps
Using an analogous procedure to that described in Example 1, 6-acetoxy-4-chloroquinazoline hydrochloride was reacted with 4-amino-2-fluorophenyl 1-methylimidazol-2-yl sulphide to give 6-acetoxy-4-[3-fluoro-4-(1-methylimidazol-2-ylthio)anilino]quinazoline dihydrochloride salt in 58% yield, m.p. 245-248 (decomposes);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821246 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-472a0a9ba0b143d4a453915915caf4c3 |
| Source note | uspto-grants-1998_10 |