4-Chloroquinazolin-6-yl acetate → 6-Acetoxy-4-[2-fluoro-4-(2-pyridylmethoxy)anilino]quinazoline

HRID 399488Notes

Reaction equation

HRID 399488 reaction equation
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][N:9]=[C:8]2Cl)(=[O:3])[CH3:2].[N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH2:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([NH2:30])=[C:26]([F:31])[CH:25]=1>>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][N:9]=[C:8]2[NH:30][C:27]1[CH:28]=[CH:29][C:24]([O:23][CH2:22][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][N:16]=2)=[CH:25][C:26]=1[F:31])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 189676244-Chloroquinazolin-6-yl acetateHCID 218478224-Amino-3-fluorophenyl 2-pyridylmethyl ether

Product 1

HCID 189676436-Acetoxy-4-[2-fluoro-4-(2-pyridylmethoxy)anilino]quinazolineYield 94%

Procedure

Using an analogous procedure to that described in Example 1, 6-acetoxy-4-chloroquinazoline was reacted with 4-amino-3-fluorophenyl 2-pyridylmethyl ether to give 6-acetoxy-4-[2-fluoro-4-(2-pyridylmethoxy)anilino]quinazoline in 94% yield.

Sources & evidence

ORD record
ord-0d3301707b814cba807c9ba799398261
Source dataset
uspto-grants-1998_10
Patent number
US05821246

Reaction notes

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