HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroquinazolin-6-yl acetate → 6-Acetoxy-4-[2-fluoro-4-(2-pyridylmethoxy)anilino]quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroquinazolin-6-yl acetate | HCID 18967624 | — |
| Reactant | 4-Amino-3-fluorophenyl 2-pyridylmethyl ether | HCID 21847822 | — |
| Product | 6-Acetoxy-4-[2-fluoro-4-(2-pyridylmethoxy)anilino]quinazoline | HCID 18967643 | 94% |
Reaction Steps
Using an analogous procedure to that described in Example 1, 6-acetoxy-4-chloroquinazoline was reacted with 4-amino-3-fluorophenyl 2-pyridylmethyl ether to give 6-acetoxy-4-[2-fluoro-4-(2-pyridylmethoxy)anilino]quinazoline in 94% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821246 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-0d3301707b814cba807c9ba799398261 |
| Source note | uspto-grants-1998_10 |