2-Chloro-N,N-dimethylethylamine → HCID 18967627, compound

HRID 399490Notes

Reaction equation

HRID 399490 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=2)=[C:17]([CH3:29])[CH:16]=1.[CH3:30][N:31]([CH3:35])[CH2:32][CH2:33]Cl>>[CH3:30][N:31]([CH3:35])[CH2:32][CH2:33][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[CH:7][N:6]=[C:5]2[NH:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=2)=[C:17]([CH3:29])[CH:16]=1

Participants

3

Reactant 2

HCID 79012-Chloro-N,N-dimethylethylamineHCID 18967588HCID 18967588, compound

Product 1

HCID 18967627HCID 18967627, compoundYield 47%

Procedure

Using an analogous procedure to that described in Example 37, 6-hydroxy-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline was reacted with 2-dimethylaminoethyl chloride to give 6-(2-dimethylaminoethoxy)-7-methoxy-4-[3-methyl-4-(2-pyridylmethoxy)anilino]quinazoline in 47% yield, m.p. 125°-126° C.;

Sources & evidence

ORD record
ord-318dd12ed00e44678e86596931e9a4ce
Source dataset
uspto-grants-1998_10
Patent number
US05821246

Reaction notes

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