HCID 18967863, compound → HCID 18967860, compound

HRID 399506Notes

Reaction equation

HRID 399506 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([O:27][C:28]2[CH:29]=[C:30]3[C:34](=[CH:35][CH:36]=2)[C:33](=[O:37])[NH:32][C:31]3=[O:38])[C:11]([NH:13][S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[CH:19][CH:18]=2)(=[O:16])=[O:15])=[O:12])=[CH:6][CH:5]=1)([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([O:27][C:28]2[CH:29]=[C:30]3[C:34](=[CH:35][CH:36]=2)[C:33](=[O:37])[NH:32][C:31]3=[O:38])[C:11]([NH:13][S:14]([C:17]2[CH:18]=[CH:19][C:20]([C:23]([CH3:26])([CH3:24])[CH3:25])=[CH:21][CH:22]=2)(=[O:16])=[O:15])=[O:12])=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 18967863HCID 18967863, compound

Product 1

HCID 18967860HCID 18967860, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A solution of 1 g of 2-(4-nitrophenyl)-2-(1,3-dihydro-1,3-dioxoisoindol-5-yloxy)-N-(4-tertbutylphenylsulfonyl)acetamide in 25 ml of methanol is hydrogenated to completion at normal pressure and 20° on 1 g of Raney nickel. The mixture is filtered, the solvent is removed and 2-(4-aminophenyl)-2-(1,3-dihydro-1,3-dioxoisoindol-5-yloxy)-N-(4-tert-butylphenylsulfonyl)acetamide is obtained.

Workup

  1. filtrationThe mixture is filtered
  2. customthe solvent is removed

Sources & evidence

ORD record
ord-6f710e43cd03414db2e55197c9f4a0f2
Source dataset
uspto-grants-1998_10
Patent number
US05821256

Reaction notes

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