1-Azabicyclo[2.2.2]octane-4-carbonitrile → Quinuclidin-4-ylmethanamine

HRID 399552Notes

Reaction equation

HRID 399552 reaction equation
[C:1]([C:3]12[CH2:10][CH2:9][N:6]([CH2:7][CH2:8]1)[CH2:5][CH2:4]2)#[N:2]>C(Cl)Cl.CO>[NH2:2][CH2:1][C:3]12[CH2:10][CH2:9][N:6]([CH2:7][CH2:8]1)[CH2:5][CH2:4]2

Participants

3

Reactant 1

HCID 1412921-Azabicyclo[2.2.2]octane-4-carbonitrile

Product 1

HCID 22056669Quinuclidin-4-ylmethanamine

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Colourless oil; Rf : 0.3 (trace of tailing; alumina; methylene chloride/methanol=7:3); Mass spectrum: M+=140; Prepared from 4-cyanoquinuclidine (see Example 3 of EP-A-0,213,337).

Sources & evidence

ORD record
ord-939eed98b7bf40c9a1e9354970f719ef
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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