HCID 178453647, Verbindung → HCID 178453642, Verbindung

HRID 399553Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 399553
[C:1]([O:5][C:6]([NH:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([NH:16]C(OCC2C=CC=CC=2)=O)[CH2:12][CH2:11]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[NH2:16][C@H:13]1[CH2:14][CH2:15][C@H:10]([CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:11][CH2:12]1

Komponenten

4

Edukt 1

HCID 178453647HCID 178453647, Verbindung

Produkt 1

HCID 178453642HCID 178453642, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1.4 g of trans-4-(tert-butyloxycarbonylaminomethyl)-benzyloxycarbonylaminocyclohexane are dissolved in 30 ml of methanol and, after addition of 0.3 g of palladium/active carbon catalyst, hydrogenated at room temperature under 50 psi for one hour. After filtration, the solvent is distilled off in a rotary evaporator. The residue is employed without purification. P Yield: 1.02 g (100% of theory) of a colourless wax,; Rf : 0.28 (alumina; -methylene chloride/methanol=10:1)

Aufarbeitung

  1. filtrationAfter filtration
  2. distillationthe solvent is distilled off in a rotary evaporator
  3. customThe residue is employed without purification

Quellen und Nachweise

ORD-Eintrag
ord-b29f6deb46364952930757c32514f44a
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05821240

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