Trifluoroacetic acid → HCID 18946131, compound

HRID 399559Notes

Reaction equation

HRID 399559 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH:21]4[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30](C)(C)C)=[O:28])[CH2:23][CH2:22]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].FC(F)(F)C(O)=O.ClC(OC)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH:21]4[CH2:26][CH2:25][N:24]([C:27]([O:29][CH3:30])=[O:28])[CH2:23][CH2:22]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 6586Methyl chloroformateHCID 18967316HCID 18967316, compound

Product 1

HCID 18946131HCID 18946131, compound

Procedure

Prepared from 4-[(3-chloro-4-fluorophenyl)amino]-6-[1-tert-butyloxycarbonyl-4-piperidinylamino]pyrimido[5,4-d]pyrimidine by reaction with trifluoroacetic acid and subsequent reaction with methyl chloroformate. Melting point: 213°-215° C,; Rf : 0.24 (silica gel; petroleum ether/ethyl acetate/methanol=20:10:1)

Sources & evidence

ORD record
ord-2a7de688ae524e1eaf908cd16bf7e24e
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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