Trifluoroacetic acid → HCID 69954514, compound

HRID 399563Notes

Reaction equation

HRID 399563 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH2:21][CH:22]4[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH2:23]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].FC(F)(F)C(O)=O.[Cl-].CO.CO>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[N:19]=[C:18]([NH:20][CH2:21][CH:22]4[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]4)[N:17]=[CH:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 86753225HCID 86753225, compoundHCID 86753226HCID 86753226, compound

Product 1

HCID 69954514HCID 69954514, compound

Procedure

Prepared from 4-[(3-chloro-4-fluorophenyl)amino]-6-[(1-tert-butyloxycarbonyl-4-piperidinyl)methylamino]pyrimido[5,4-d]pyrimidine by reaction with trifluoroacetic acid. Melting point: 204°-206° C.; Rf : 0.42 (alumina; methanol chloride/methanol=10:1)

Sources & evidence

ORD record
ord-e887f47636d441cab82d310b5925916f
Source dataset
uspto-grants-1998_10
Patent number
US05821240

Reaction notes

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