Hydrogen chloride-ethyl acetate → HCID 67538741, compound

HRID 39957Notes

Reaction equation

HRID 39957 reaction equation
[CH2:1]([C:3]1[CH:30]=[CH:29][C:6]([CH2:7][NH:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([F:27])[CH:25]=4)[N:20]=[CH:19][C:18]3=[O:28])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[ClH:31].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:31].[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:7][NH:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][N:17]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([F:27])[CH:25]=4)[N:20]=[CH:19][C:18]3=[O:28])[CH2:13][CH2:14]2)=[CH:29][CH:30]=1)[CH3:2]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593982381-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one

Product 1

HCID 67538741HCID 67538741, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 10 mL of an ethyl acetate solution containing 1-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature for 10 min. The resulting solid was filtered to give 292 mg of 1-(2-(4-(4-ethylbenzylamino)piperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one hydrochloride as a pale brown solid.

Workup

  1. additionwas added
  2. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-c7db65a28c624b1eb29a67f9bcc04bb5
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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