HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 15291612, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(2,4-dichlorophenyl)-5-methyl-2-{N-[alpha-cyclopropyl-4-(hydroxymethyl)benzyl]N-propylamino}thiazole | HCID 15291611 | — |
| Catalyst | Acetic Anhydride | HCID 7918 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 15291612 | HCID 15291612 | — |
Reaction Steps
0.6 ml of acetic anhydride and 4-dimethylaminopyridine as catalyst are added, in the presence of 0.3 ml of triethylamine, to 930 g of the compound of Example 4 dissolved in 50 ml of methylene chloride. After stirring for 1 hour at room temperature, a large excess of methanol is added and the reaction medium is then evaporated under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821255 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-5c8622bbeaea43ed847ff138667367b2 |
| Source note | uspto-grants-1998_10 |