Methanol → HCID 15291612, compound

HRID 399632Notes

Reaction equation

HRID 399632 reaction equation
C(N([CH2:6][CH3:7])CC)C.[Cl:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[C:16]1[N:17]=[C:18]([N:22]([CH:26]([CH:35]2[CH2:37][CH2:36]2)[C:27]2[CH:32]=[CH:31][C:30]([CH2:33][OH:34])=[CH:29][CH:28]=2)[CH2:23][CH2:24][CH3:25])[S:19][C:20]=1[CH3:21].C[OH:39]>C(OC(=O)C)(=O)C.CN(C)C1C=CN=CC=1.C(Cl)Cl>[Cl:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[C:16]1[N:17]=[C:18]([N:22]([CH:26]([CH:35]2[CH2:36][CH2:37]2)[C:27]2[CH:28]=[CH:29][C:30]([CH2:33][O:34][C:6](=[O:39])[CH3:7])=[CH:31][CH:32]=2)[CH2:23][CH2:24][CH3:25])[S:19][C:20]=1[CH3:21]

Participants

7

Reactant 3

HCID 887MethanolHCID 8471TriethylamineHCID 152916114-(2,4-dichlorophenyl)-5-methyl-2-{N-[alpha-cyclopropyl-4-(hydroxymethyl)benzyl]N-propylamino}thiazole

Product 1

HCID 15291612HCID 15291612, compound

Reagents, catalysts & solvents 3

HCID 7918Acetic AnhydrideCatalystHCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

0.6 ml of acetic anhydride and 4-dimethylaminopyridine as catalyst are added, in the presence of 0.3 ml of triethylamine, to 930 g of the compound of Example 4 dissolved in 50 ml of methylene chloride. After stirring for 1 hour at room temperature, a large excess of methanol is added and the reaction medium is then evaporated under vacuum.

Workup

  1. customthe reaction medium is then evaporated under vacuum

Sources & evidence

ORD record
ord-5c8622bbeaea43ed847ff138667367b2
Source dataset
uspto-grants-1998_10
Patent number
US05821255

Reaction notes

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