HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 4-(2,4-dichlorophenyl)-5-methyl-2-{N-[alpha-cyclopropyl-4-(iodmethyl)benzyl]N-propylamino}thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Iodine | HCID 807 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 4-(2,4-dichlorophenyl)-5-methyl-2-{N-[alpha-cyclopropyl-4-(hydroxymethyl)benzyl]N-propylamino}thiazole | HCID 15291611 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(2,4-dichlorophenyl)-5-methyl-2-{N-[alpha-cyclopropyl-4-(iodmethyl)benzyl]N-propylamino}thiazole | HCID 15291613 | — |
Reaction Steps
0.35 g of imidazole, 1.32 g of iodine and then 1.6 g of the product of Example 4 are added, at room temperature, to 1.36 g of triphenylphosphine in 50 ml of methylene chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05821255 |
| Source dataset | uspto-grants-1998_10 |
| ORD ID | ord-583331f87e164a06a4aab7d983e5625f |
| Source note | uspto-grants-1998_10 |