Imidazole → 4-(2,4-dichlorophenyl)-5-methyl-2-{N-[alpha-cyclopropyl-4-(iodmethyl)benzyl]N-propylamino}thiazole

HRID 399633Notes

Reaction equation

HRID 399633 reaction equation
N1C=CN=C1.[I:6]I.[Cl:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[C:16]1[N:17]=[C:18]([N:22]([CH:26]([CH:35]2[CH2:37][CH2:36]2)[C:27]2[CH:32]=[CH:31][C:30]([CH2:33]O)=[CH:29][CH:28]=2)[CH2:23][CH2:24][CH3:25])[S:19][C:20]=1[CH3:21].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[Cl:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[C:16]1[N:17]=[C:18]([N:22]([CH:26]([CH:35]2[CH2:37][CH2:36]2)[C:27]2[CH:32]=[CH:31][C:30]([CH2:33][I:6])=[CH:29][CH:28]=2)[CH2:23][CH2:24][CH3:25])[S:19][C:20]=1[CH3:21]

Participants

6

Reactant 4

HCID 795ImidazoleHCID 807IodineHCID 11776TriphenylphosphineHCID 152916114-(2,4-dichlorophenyl)-5-methyl-2-{N-[alpha-cyclopropyl-4-(hydroxymethyl)benzyl]N-propylamino}thiazole

Product 1

HCID 152916134-(2,4-dichlorophenyl)-5-methyl-2-{N-[alpha-cyclopropyl-4-(iodmethyl)benzyl]N-propylamino}thiazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.35 g of imidazole, 1.32 g of iodine and then 1.6 g of the product of Example 4 are added, at room temperature, to 1.36 g of triphenylphosphine in 50 ml of methylene chloride.

Sources & evidence

ORD record
ord-583331f87e164a06a4aab7d983e5625f
Source dataset
uspto-grants-1998_10
Patent number
US05821255

Reaction notes

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