Carbon Dioxide → 4-(2,4-dicarboxyphenyl)-5-methyl-2-[N-(alpha-cyclopropylbenzyl)-N-propylamino]thiazole

Participants

Reaction Steps

5 ml of a 1.7M solution of tert-butyllithium in pentane are added, at -70° C., to 1.1 g of 4-(2,4-dibromophenyl)-5-methyl-2-[N-(α-cyclopropylbenzyl)-N-propylamino]thiazole (prepared from 2-bromo-1-(2,4-dibromophenyl)-1-propanone (Compound 14) and N-(α-cyclopropylbenzyl)-N-propylthiourea (Compound 65), according to the process described in Example 1, Step A), dissolved in 30 ml of anhydrous ethyl ether. The temperature is allowed to rise to -50° C. and the mixture is then subjected to the action of carbon dioxide, allowing the temperature to rise to 20° C.

Provenance & Evidence