HRID399637

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID280

Carbon dioxide

CO2

HCID3283

Diethyl Ether

C4H10O

HCID18967754

未命名化合物

2 次

HCID18967810

未命名化合物

2 次

结构：CCCN(c1nc(-c2ccc(Br)cc2Br)c(C)s1)C(c1ccccc1)C1CC1

HCID18967833

未命名化合物

HCID178418306

未命名化合物

PRODUCTS

生成物

结构：CCCN(c1nc(-c2ccc(C(=O)O)cc2C(=O)O)c(C)s1)C(c1ccccc1)C1CC1

HCID18967803

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8003

Pentane

C5H12

PROCEDURE

实验过程

5 ml of a 1.7M solution of tert-butyllithium in pentane are added, at -70° C., to 1.1 g of 4-(2,4-dibromophenyl)-5-methyl-2-[N-(α-cyclopropylbenzyl)-N-propylamino]thiazole (prepared from 2-bromo-1-(2,4-dibromophenyl)-1-propanone (Compound 14) and N-(α-cyclopropylbenzyl)-N-propylthiourea (Compound 65), according to the process described in Example 1, Step A), dissolved in 30 ml of anhydrous ethyl ether. The temperature is allowed to rise to -50° C. and the mixture is then subjected to the action of carbon dioxide, allowing the temperature to rise to 20° C.

WORKUP

后处理

customto rise to -50° C.
customto rise to 20° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-79a105e8bb0e4a459e9296d641bfcd60
来源数据集: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05821255
来源说明: uspto-grants-1998_10

反应 SMILES

C([Li])(C)(C)C.Br[C:7]1[CH:12]=[C:11](Br)[CH:10]=[CH:9][C:8]=1[C:14]1[N:15]=[C:16]([N:20]([CH:24]([CH:31]2[CH2:33][CH2:32]2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:21][CH2:22][CH3:23])[S:17][C:18]=1[CH3:19].BrC(C)[C:36](C1C=CC(Br)=CC=1Br)=[O:37].C1(C(N(CCC)C(N)=S)C2C=CC=CC=2)CC1.[C:64](=[O:66])=[O:65].C([O:69]CC)C>CCCCC>[C:64]([C:7]1[CH:12]=[C:11]([C:36]([OH:37])=[O:69])[CH:10]=[CH:9][C:8]=1[C:14]1[N:15]=[C:16]([N:20]([CH:24]([CH:31]2[CH2:33][CH2:32]2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:21][CH2:22][CH3:23])[S:17][C:18]=1[CH3:19])([OH:66])=[O:65]