Water → 3-Chloro-4-ethylsulfonyl-1,2,5-thiadiazole

HRID 399649Notes

Reaction equation

HRID 399649 reaction equation
[OH:1]OS([O-])=O.[K+].[Cl:7][C:8]1[C:12]([S:13][CH2:14][CH3:15])=[N:11][S:10][N:9]=1.[OH2:16]>C1COCC1>[Cl:7][C:8]1[C:12]([S:13]([CH2:14][CH3:15])(=[O:1])=[O:16])=[N:11][S:10][N:9]=1

Participants

5

Reactant 3

HCID 962WaterHCID 108212623-Chloro-4-ethylthio-1,2,5-thiadiazoleHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 105365353-Chloro-4-ethylsulfonyl-1,2,5-thiadiazole

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of Oxone (84 g, 0.137 mol) in H2O (400 mL) was rapidly stirred as 3-chloro-4-ethylthio-1,2,5-thiadiazole (12.2 g, 0.067 mol) in THF (200 mL) was added. After stirring overnight, the THF was evaporated and the residue extracted with ether (3×). The extracts were washed with H2O, aqueous NaHCO3, and brine then the solvent dried and evaporated to give a clear liquid (13.6 g). (Compound 4).

Workup

  1. additionwas added
  2. customthe THF was evaporated
  3. extractionthe residue extracted with ether (3×)
  4. washThe extracts were washed with H2O, aqueous NaHCO3, and brine
  5. customthe solvent dried
  6. customevaporated

Sources & evidence

ORD record
ord-073ff6a95ea74417936a4ea38de80b1f
Source dataset
uspto-grants-1998_10
Patent number
US05821370

Reaction notes

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