反应详情

(4S,5R)-N-(t-butylaminocarbonyl)-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid methyl ester (Example No. 22, 28b, 0.98 g, 2.2 mM) is stirred at room temperature under nitrogen in methanol (50 mL). To this is added a solution of potassium carbonate (0.39 g, 2.5 mM) in water (1.1 mL). After 5 hours the reaction is evaporated under reduced pressure to remove the methanol and the residue freeze dried. There is obtained a quantitative yield of (4S,5R)-N-Boc-2-(2,4-dimethoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid potassium salt (29b) admixed with potassium carbonate salts as a powder.

1. customAfter 5 hours the reaction is evaporated under reduced pressure
2. customto remove the methanol
3. customthe residue freeze dried