Chloroform → HCID 67539378, compound

HRID 39971Notes

Reaction equation

HRID 39971 reaction equation
C(Cl)(Cl)[Cl:2].[F:5][C:6]1[CH:7]=[C:8]([CH:32]=[CH:33][C:34]=1[CH3:35])[CH2:9][NH:10][CH:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:29][CH3:30])[CH:27]=3)[N:22]=[CH:21][C:20]2=[O:31])[CH2:13][CH2:12]1.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[ClH:2].[F:5][C:6]1[CH:7]=[C:8]([CH:32]=[CH:33][C:34]=1[CH3:35])[CH2:9][NH:10][CH:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:29][CH3:30])[CH:27]=3)[N:22]=[CH:21][C:20]2=[O:31])[CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 21866389Hydrogen chloride-ethyl acetateHCID 593982681-(2-(4-(3-fluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one

Product 1

HCID 67539378HCID 67539378, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixed solution of 10 mL chloroform and 4 mL ethyl acetate containing 0.44 g of 1-(2-(4-(3-fluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one, 2 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 422 mg of 1-(2-(4-(3-fluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride as a brown solid.

Workup

  1. customThe solvent was removed under reduced pressure, ethyl acetate
  2. additionwas added
  3. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-06d3fa53dc9c4d1295fd30df79056ccf
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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