Benzyl Bromide → HCID 18945033, compound

HRID 399741Notes

Reaction equation

HRID 399741 reaction equation
[CH2:1]([O:8][C:9]1[C:10]2[N:11]([C:15]([CH3:19])=[C:16]([CH3:18])[N:17]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:20]([Br:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CC(C)=O>[Br-:27].[CH2:20]([N+:17]1[C:16]([CH3:18])=[C:15]([CH3:19])[N:11]2[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:10]=12)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 9992399HCID 9992399, compound

Product 1

HCID 18945033HCID 18945033, compoundYield 104.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 2 g of 8-benzyloxy-2,3-dimethylimidazo-[1,2-a]pyridine at 50° C., dissolved in 40 ml of anhydrous acetone, is treated with 2.7 g of benzyl bromide and then heated under reflux for 16 h. The precipitate produced in this process is filtered- off and washed with cold acetone. 3.5 g of the title compound of m.p. 190°-192° C. are obtained.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 16 h
  3. customThe precipitate produced in this process
  4. washwashed with cold acetone

Sources & evidence

ORD record
ord-70c2c234df874006914e2beeb4fc3edb
Source dataset
uspto-grants-1998_10
Patent number
US05824687

Reaction notes

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