Jineol → Jineol acetate

HRID 399743노트

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HRID 399743 반응식
[CH:1]1[CH:10]=[C:9]([OH:11])[C:8]2[N:7]=[CH:6][C:5]([OH:12])=[CH:4][C:3]=2[CH:2]=1>C(OC(=O)C)(=O)C.N1C=CC=CC=1.C(OCC)(=O)C>[C:9]([O:12][C:5]1[CH:6]=[N:7][C:8]2[C:3]([CH:4]=1)=[CH:2][CH:1]=[CH:10][C:9]=2[O:11][C:5](=[O:12])[CH3:4])(=[O:11])[CH3:8]

참가 물질

5

반응물 1

HCID 177338Jineol

생성물 1

HCID 10490562Jineol acetate수율 78%

시약·촉매·용매 3

HCID 1049Pyridine용매HCID 7918Acetic Anhydride용매HCID 8857Ethyl Acetate용매

실험 절차

Jineol of 5.0 mg was dissolved in 0.5 ml of acetic acid anhydride and 0.5 ml of pyridine, and then the solution was agitated at room temperature for 9 hours. After the solution was diluted with ethyl acetate, it was washed with sodium dicarbonate solution and brine. The solution was dried with anhydrous magnesium sulfate anhydride. After the residue was removed, the solution was purified by silicagel chromatography to give 5.9 mg of 3,8-diacetoxy quinoline with 78% yield.

후처리

  1. washwas washed with sodium dicarbonate solution and brine
  2. dry with materialThe solution was dried with anhydrous magnesium sulfate anhydride
  3. customAfter the residue was removed
  4. customthe solution was purified by silicagel chromatography

출처 및 근거

ORD 기록
ord-7629a4443b2049788e37e444ef2123bd
출처 데이터셋
uspto-grants-1998_10
특허 번호
US05824689

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