反应详情

温度

0 °C

In 53 ml of 33%(v/v) sulfuric acid was dissolved 6.2 g of 3-amino-8-methoxy quinoline [compound (IV)]. The solution was cooled to 0° C., and to the solution was slowly dropped 2.6 g of sodium nitrite which is dissolved in 12 ml of water. The solution was agitated at 0° to 5° C. for 30 minutes. The resulting solution was dropped in 47 ml of 50%(v/v) which was kept 160° C., agitated for 1 hour, and cooled. To the solution was added 300 ml of water and neutralized with aqueous potassium carbonate. By filtering and drying the solid portion, 3.8 g of 3-hydroxy-8-methoxy quinoline [compound (V)], which is yellow-red, was obtained in a solid state.

1. additionThe resulting solution was dropped in 47 ml of 50%(v/v) which
2. customwas kept 160° C.
3. stirringagitated for 1 hour
4. temperaturecooled
5. filtrationBy filtering
6. dry with materialdrying the solid portion, 3.8 g of 3-hydroxy-8-methoxy quinoline [compound (V)], which
7. customwas obtained in a solid state