反应详情

The mixture of methyl 5-(3-dimethylamino-1-oxo-2-propenyl)-3-pyridinecarboxylate (1.7 g), acetic acid (0.62 ml) and hydrazine monohydrate (0.53 ml) in methanol (34 ml) was stirred for 24 hours at ambient temperature, and the mixture was evaporated in vacuo. To the residue was added a mixture of tetrahydrofuran, ethyl acetate and water, and the mixture was adjusted to pH 9 with potassium carbonate. The separated organic layer was washed with brine and dried over magnesium sulfate. The solvent was removed by concentration and the residue was triturated with diisopropyl ether to give methyl 5-(pyrazol-3-yl)-3-pyridinecarboxylate (1.24 g).

1. customthe mixture was evaporated in vacuo
2. additionTo the residue was added
3. additiona mixture of tetrahydrofuran, ethyl acetate and water
4. washThe separated organic layer was washed with brine
5. dry with materialdried over magnesium sulfate
6. customThe solvent was removed by concentration
7. customthe residue was triturated with diisopropyl ether