反应详情

Thionyl chloride (2.5 ml) was added dropwise in methanol (25 ml) under cooling at 7°-9° C. After the mixture was stirred for 30 minutes at the same temperature, 5-(3-methyl-1,2,4-oxadiazol-5-yl)-3-pyridinecarboxylic acid (2.5 g) was added thereto and the mixture was refluxed for 3 hours. After being cooled to room temperature, the mixture was poured into a mixture of ethyl acetate (100 ml) and water (100 ml). The organic layer was successively washed with 10% potassium carbonate aqueous solution and brine, and then dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was recrystallized from diethyl ether to afford methyl 5-(3-methyl-1,2,4-oxadiazol-5-yl)-3-pyridinecarboxylate (2.12 g).

1. temperatureunder cooling at 7°-9° C
2. additionwas added
3. temperaturethe mixture was refluxed for 3 hours
4. washThe organic layer was successively washed with 10% potassium carbonate aqueous solution and brine
5. dry with materialdried over magnesium sulfate
6. customThe solvent was evaporated in vacuo
7. customthe residue was recrystallized from diethyl ether