反应详情

Acetic anhydride (1.3 ml) was added to a mixture of aluminum chloride (2.7 g) and 1,2-dichloroethane (10 ml) under ice-cooling and the mixture was stirred for 20 minutes at the same temperature. To the mixture was added dropwise a mixture of methyl 3-(pyrrol-1-yl)benzoate (2.0 g) in dichloroethane (3 ml) for 10 minutes at 0° to 5° C., and the mixture was stirred for 3 hours at the same temperature. The reaction mixture was poured into an ice-water and the mixture was extracted with chloroform. The extract was washed with a saturated aqueous sodium bicarbonate solution and water. The organic layer was dried over magnesium sulfate and evaporated in vacuo to give methyl 3-(2-acetylpyrrol-1-yl)benzoate (0.94 g).

1. temperaturecooling
2. additionTo the mixture was added dropwise
3. stirringthe mixture was stirred for 3 hours at the same temperature
4. extractionthe mixture was extracted with chloroform
5. washThe extract was washed with a saturated aqueous sodium bicarbonate solution and water
6. dry with materialThe organic layer was dried over magnesium sulfate
7. customevaporated in vacuo