反应详情

The solution of methyl 3-(2-formylpyrrol-1-yl)benzoate (1.0 g) and benzyl (triphenylphosphoranylidene)acetate (1.8 g) in tetrahydrofuran (10 ml) were heated under reflux for 30 hours. After evaporating the solvent, the residue was purified by column chromatography on silica gel eluting with toluene. The fractions containing the desired product were collected and evaporated in vacuo to give methyl 3-[2-((E)-2-benzyloxycarbonylethenyl)pyrrol-1-yl)benzoate (0.77 g) as an oil.

1. temperatureunder reflux for 30 hours
2. customAfter evaporating the solvent
3. customthe residue was purified by column chromatography on silica gel eluting with toluene
4. additionThe fractions containing the desired product
5. customwere collected
6. customevaporated in vacuo