反应详情

Benzylbromide (2.9 ml) was added to the mixture of methyl 4-hydroxy-3-(pyrrol-1-yl)benzoate (5.0 g) and potassium t-butoxide (2.7 g) in N,N-dimethylformamide (40 ml) under ice-cooling and the mixture was stirred for 5 hours at ambient temperature. The reaction mixture was poured into water and extracted with ethyl acetate. The extract layer was washed with brine and dried over magnesium sulfate. The solvent was removed by concentration. The residue was crystallized from the mixture of toluene and diisopropyl ether and collected by filtration to give methyl 4-benzyloxy3-(pyrrol-1-yl)benzoate (4.2 g).

1. temperaturecooling
2. extractionextracted with ethyl acetate
3. washThe extract layer was washed with brine
4. dry with materialdried over magnesium sulfate
5. customThe solvent was removed by concentration
6. customThe residue was crystallized from the mixture of toluene and diisopropyl ether
7. filtrationcollected by filtration