Hydrogen chloride-ethyl acetate → 1-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride

HRID 39984Notes

Reaction equation

HRID 39984 reaction equation
[C:1]1([C:7]#[C:8][CH2:9][N:10]([CH2:32][C:33]#[C:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([O:29][CH3:30])[CH:27]=4)[N:22]=[CH:21][C:20]3=[O:31])[CH2:13][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:41].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:41].[C:35]1([C:34]#[C:33][CH2:32][N:10]([CH2:9][C:8]#[C:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]3[C:28]4[C:23](=[CH:24][CH:25]=[C:26]([O:29][CH3:30])[CH:27]=4)[N:22]=[CH:21][C:20]3=[O:31])[CH2:13][CH2:12]2)[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59398234HCID 59398234, compound

Product 1

HCID 675392911-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 5 mL of an ethyl acetate solution containing 0.24 g of 1-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one, 2 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature. The resulting solid was filtered to give 224 mg of 1-(2-(4-(bis(3-phenyl-2-propyn-1-yl)amino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride as a brown solid.

Workup

  1. additionwas added
  2. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-109a1fa64fa34594b68520755c991592
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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