Hydrogen chloride-ethyl acetate → HCID 67538451, compound

HRID 39990Notes

Reaction equation

HRID 39990 reaction equation
[Cl:1][C:2]1[C:11]([CH2:12][NH:13][CH:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][N:22]3[C:31]4[C:26](=[CH:27][CH:28]=[C:29]([O:32][CH3:33])[CH:30]=4)[N:25]=[CH:24][C:23]3=[O:34])[CH2:16][CH2:15]2)=[N:10][C:9]2[N:8]([CH3:35])[C:7](=[O:36])[CH2:6][S:5][C:4]=2[CH:3]=1.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[C:11]([CH2:12][NH:13][CH:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][N:22]3[C:31]4[C:26](=[CH:27][CH:28]=[C:29]([O:32][CH3:33])[CH:30]=4)[N:25]=[CH:24][C:23]3=[O:34])[CH2:16][CH2:15]2)=[N:10][C:9]2[N:8]([CH3:35])[C:7](=[O:36])[CH2:6][S:5][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59398030HCID 59398030, compound

Product 1

HCID 67538451HCID 67538451, compoundYield 188.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 5 mL of an ethyl acetate solution containing 0.16 g of 1-(2-(4-((7-chloro-4-methyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one, 2 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature. The resulting solid was filtered to give 161 mg of 1-(2-(4-((7-chloro-4-methyl-3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride as a yellow solid.

Workup

  1. additionwas added
  2. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-2b82f60ba11840039291be7ab5062bea
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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