Hydrochloric Acid → HCID 67560555, compound

HRID 399971Notes

Reaction equation

HRID 399971 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][C:31]([C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)([C:34]([NH2:36])=[O:35])[CH2:30][CH2:29]3)[CH2:13][CH2:12][N:11]([C:14](=[O:25])[C:15]3[C:20]([O:21][CH3:22])=[CH:19][CH:18]=[CH:17][C:16]=3[O:23][CH3:24])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>ClCCl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:26][CH2:27][N:28]3[CH2:29][CH2:30][C:31]([C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)([C:34]([NH2:36])=[O:35])[CH2:32][CH2:33]3)[CH2:13][CH2:12][N:11]([C:14](=[O:25])[C:15]3[C:16]([O:23][CH3:24])=[CH:17][CH:18]=[CH:19][C:20]=3[O:21][CH3:22])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 44212281HCID 44212281, compound

Product 1

HCID 67560555HCID 67560555, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

1-[2-[3-(3,4-Dichloro-phenyl)-1-(2,6-dimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide (1.8 mmol) was dissolved in dichloromethane (20 mL) and treated with a solution of dichloromethane saturated with HCl(g) (20 mL). The solution was allowed to stir for 1 h. The solution was concentrated in vacuo to obtain a residue. The residue was dried under high vacuum at 56° C. for 18 h to give the title compound. Analysis: calculated for C33H38Cl3N3 O4C 61.26; H 5.92; N 6.49; Found C 61.18; H 6.22; N 6.57.

Workup

  1. concentrationThe solution was concentrated in vacuo
  2. customto obtain a residue
  3. customThe residue was dried under high vacuum at 56° C. for 18 h

Sources & evidence

ORD record
ord-64dba4b00ad64819904c13910d2338f3
Source dataset
uspto-grants-1998_10
Patent number
US05824690

Reaction notes

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