HRID399974

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

结构：COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC.Cl

HCID53462564

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC

HCID9874168

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8003

Pentane

C5H12

PROCEDURE

实验过程

A racemic mixture of 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (120 mg, 0.18 mmol) was resolved into two enantiomers on a CHIRALPAK AD chiral HPLC column (25 cm×2 cm) using 15% methanol in pentane to give the title compound: Rt =10 minutes for (-)-1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f82fdb60c2be412fb1307b4b4db39a6d
来源数据集: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05824690
来源说明: uspto-grants-1998_10

反应 SMILES

Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2([CH2:29][CH2:30][N:31]3[CH2:36][CH2:35][C:34]([C:40]4[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=4)([C:37]([NH2:39])=[O:38])[CH2:33][CH2:32]3)[CH2:14][CH2:13][N:12]([C:15](=[O:28])[C:16]3[CH:21]=[C:20]([O:22][CH3:23])[C:19]([O:24][CH3:25])=[C:18]([O:26][CH3:27])[CH:17]=3)[CH2:11]2)[CH:6]=[CH:7][C:8]=1[Cl:9].CO>CCCCC>[Cl:2][C:3]1[CH:4]=[C:5]([C:10]2([CH2:29][CH2:30][N:31]3[CH2:36][CH2:35][C:34]([C:40]4[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=4)([C:37]([NH2:39])=[O:38])[CH2:33][CH2:32]3)[CH2:14][CH2:13][N:12]([C:15](=[O:28])[C:16]3[CH:21]=[C:20]([O:22][CH3:23])[C:19]([O:24][CH3:25])=[C:18]([O:26][CH3:27])[CH:17]=3)[CH2:11]2)[CH:6]=[CH:7][C:8]=1[Cl:9]