Hydrochloric Acid → 4-(Pyridin-4-yl)-piperidine-4-carboxylic acid amide hydrochloride

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Reaction Steps

Combine 1-benzyl-(4-(pyridin-4-yl)-piperidine-4-carboxylic acid amide, (0.22 g, 0.67 mmol) and ethanol (20 mL). Add 5% palladium-on-carbon (0.14 g) and hydrogenate on a Parr apparatus at 55 psi. After 48 hours, remove the catalyst by filtration and evaporate the filtrate in vacuo to give a residue. Combine the residue and methanol. Add a solution of hydrochloric acid in dioxane (2 mL, 4M, 8 mmol) to give a solid. Collect the solid by filtration to give 4-(pyridin-4-yl)-piperidine-4-carboxylic acid amide hydrochloride.

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