反应详情

Combine 1-benzyl-(4-(pyridin-4-yl)-piperidine-4-carboxylic acid amide, (0.22 g, 0.67 mmol) and ethanol (20 mL). Add 5% palladium-on-carbon (0.14 g) and hydrogenate on a Parr apparatus at 55 psi. After 48 hours, remove the catalyst by filtration and evaporate the filtrate in vacuo to give a residue. Combine the residue and methanol. Add a solution of hydrochloric acid in dioxane (2 mL, 4M, 8 mmol) to give a solid. Collect the solid by filtration to give 4-(pyridin-4-yl)-piperidine-4-carboxylic acid amide hydrochloride.

1. customremove the catalyst
2. filtrationby filtration
3. customevaporate the filtrate in vacuo
4. customto give a residue
5. customto give a solid
6. customCollect the solid
7. filtrationby filtration