HRID400072

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6344

Dichloromethane

CH2Cl2

HCID8857

Ethyl acetate

C4H8O2

结构：CN1CCN(C(N)=O)CC1.Cl.O=C(O)C1(c2ccccc2)CCNCC1

HCID67562154

未命名化合物

结构：O=C(c1ccccc1)N1CC[C@@](CCCS(=O)(=O)[O-])(c2ccc(Cl)c(Cl)c2)C1

HCID86753254

未命名化合物

PRODUCTS

生成物

结构：CN1CCN(C(N)=O)CC1.O=C(c1ccccc1)N1CC[C@](CCN2CCC(C(=O)O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1

HCID131720897

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21226129

未命名化合物

4 次

PROCEDURE

实验过程

Prepare by the method of Example 88.6 using (S)-2-[3-(3,4-dichloro-phenyl)-1-(benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate and 4-phenyl-piperidine-4-carboxylic acid 4-methylpiperazine-amide hydrochloride to give, after chromatography on silica gel eluting sequentially with ethyl acetate, dichloromethane, 2% methanol/dichloromethane, 4% methanol/dichloromethane, 6% methanol/dichloromethane, and then 8% methanol/dichloromethane, the title compound: Rf =0.27 (silica gel, methanol/dichloromethane 1/9).

WORKUP

后处理

customto give

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-af0e5feeed9341999439c72e771153fd
来源数据集: uspto-grants-1998_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05824690
来源说明: uspto-grants-1998_10

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([C@:9]2([CH2:22][CH2:23]CS([O-])(=O)=O)[CH2:13][CH2:12][N:11]([C:14](=[O:21])[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[CH3:30][N:31]1[CH2:36][CH2:35][N:34]([C:37]([NH2:39])=[O:38])[CH2:33][CH2:32]1.[C:40]1([C:46]2([C:52]([OH:54])=[O:53])[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]2)[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1.C(OCC)(=O)C.ClCCl>CO.ClCCl>[CH3:30][N:31]1[CH2:36][CH2:35][N:34]([C:37]([NH2:39])=[O:38])[CH2:33][CH2:32]1.[Cl:1][C:2]1[CH:3]=[C:4]([C@@:9]2([CH2:22][CH2:23][N:49]3[CH2:48][CH2:47][C:46]([C:40]4[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=4)([C:52]([OH:54])=[O:53])[CH2:51][CH2:50]3)[CH2:13][CH2:12][N:11]([C:14](=[O:21])[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]