Formic Acid → Methyl 3-formamidocinnamate

HRID 400089Notes

Reaction equation

HRID 400089 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[CH:5]=[CH:6][C:7]([O:9][CH3:10])=[O:8].[CH:14](O)=[O:15]>O>[CH:14]([NH:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[CH:5]=[CH:6][C:7]([O:9][CH3:10])=[O:8])=[O:15]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 54385173Methyl 3-aminocinnamate

Product 1

HCID 54484240Methyl 3-formamidocinnamate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

193 g of methyl 3-aminocinnamate and 900 ml of formic acid were mixed and heated under reflux for 2 hours. The reaction solution was poured into water and the crystals (methyl 3-formamidocinnamate) obtained were collected by filtration. Yield: 127 g.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 2 hours

Sources & evidence

ORD record
ord-544208453dae4717be0d51f4b646578f
Source dataset
uspto-grants-1998_10
Patent number
US05827638

Reaction notes

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