2,2-Diethoxyethylamine → HCID 18943443, compound

HRID 400104Notes

Reaction equation

HRID 400104 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:15]([O:17][CH:18]([O:21][CH2:22][CH3:23])[CH2:19][NH2:20])[CH3:16]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:20][CH2:19][CH:18]([O:21][CH2:22][CH3:23])[O:17][CH2:15][CH3:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 695242,2-DiethoxyethylamineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 18943443HCID 18943443, compoundYield 5%

Procedure

The N-(1-tert-butyloxycarbonyl-4-piperidinyl)-N-(2,2-di-ethoxyethyl)amine [Rf : 0.48 (reversed phase silica gel; methanol/5% aqueous brine=6:4)] employed is prepared by reductive amination of 1-tert-butyloxycarbonyl-4-piperidone with aminoacetaldehyde diethyl acetal

Sources & evidence

ORD record
ord-ba2225c8df2545d0bd2e72a772527e62
Source dataset
uspto-grants-1998_10
Patent number
US05827849

Reaction notes

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