Hydrochloric Acid → HCID 178471544, compound

HRID 400116Notes

Reaction equation

HRID 400116 reaction equation
Cl.[C:2]([CH2:5][CH2:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([N:13]2[CH2:17][CH2:16][N:15]([C:18]3[CH:19]=[N:20][C:21]4[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23][C:22]=4[N:29]=3)[C:14]2=[O:30])[CH2:9][CH2:8]1)([OH:4])=[O:3].[CH2:31](O)[CH3:32]>>[CH2:31]([O:3][C:2]([CH2:5][CH2:6][C@H:7]1[CH2:8][CH2:9][C@H:10]([N:13]2[CH2:17][CH2:16][N:15]([C:18]3[CH:19]=[N:20][C:21]4[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23][C:22]=4[N:29]=3)[C:14]2=[O:30])[CH2:11][CH2:12]1)=[O:4])[CH3:32]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 178480128HCID 178480128, compound

Product 1

HCID 178471544HCID 178471544, compound

Procedure

Gaseous hydrogen chloride is passed into 1.0 g of 1-[trans-4-(2-carboxyethyl)cyclohexyl]-3-(7-methyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepin-2-yl)imidazolidin-2-one in 30 ml of ethanol for 10 minutes and the mixture is subsequently heated under reflux for 1 hour. After standing at room temperature overnight, it is again heated to reflux, cooled and concentrated. The residue is stirred with dilute aqueous sodium carbonate solution. The solid is filtered off with suction, washed with water and dried.

Workup

  1. temperaturethe mixture is subsequently heated
  2. temperatureunder reflux for 1 hour
  3. temperatureit is again heated
  4. temperatureto reflux
  5. temperaturecooled
  6. concentrationconcentrated
  7. filtrationThe solid is filtered off with suction
  8. washwashed with water
  9. customdried

Sources & evidence

ORD record
ord-5c8241b08b10450ab71675b5c43f5601
Source dataset
uspto-grants-1998_10
Patent number
US05827849

Reaction notes

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