Hydrogen chloride-ethyl acetate → HCID 67539942, compound

HRID 40016Notes

Reaction equation

HRID 40016 reaction equation
[O:1]1[C:10]2[C:5](=[N:6][C:7]([CH2:11][NH:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[CH:26][CH:27]=[C:28]([O:31][CH3:32])[CH:29]=5)[N:24]=[CH:23][C:22]4=[O:33])[CH2:15][CH2:14]3)=[CH:8][CH:9]=2)[O:4][CH2:3][CH2:2]1.[ClH:34].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:34].[O:1]1[C:10]2[C:5](=[N:6][C:7]([CH2:11][NH:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[CH:26][CH:27]=[C:28]([O:31][CH3:32])[CH:29]=5)[N:24]=[CH:23][C:22]4=[O:33])[CH2:15][CH2:14]3)=[CH:8][CH:9]=2)[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59398343HCID 59398343, compound

Product 1

HCID 67539942HCID 67539942, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 2 mL of an ethyl acetate solution containing 95.0 mg of 1-(2-(4-((2,3-dihydro-1,4-dioxino[2,3-b]pyridin-6-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature. The resulting solid was filtered to give 104 mg of 1-(2-(4-((2,3-dihydro-1,4-dioxino[2,3-b]pyridin-6-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride as a yellow powder.

Workup

  1. additionwas added
  2. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-8ab0b9efa94b49ecaf8a51bb0d38e665
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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