反应详情

A! 200 ml (1.49 moles) of hexylamine cooled to 5° C. were added with benzyl bromide (42.3 ml, 0.35 mole), and the resultant mixture was stirred for 1 hour at room temperature. The hexylamine in excess was then distilled off under vacuum, and the residue dissolved in 300 ml of ethyl ether and washed with 200 ml of 0.5N sodium hydroxide. The ether phase was anhydrified over sodium sulfate and evaporated to dryness thus yielding 75.5 g of a crude which, by distillation under vacuum, gave 59 g (yield: 89%) of N-benzyl-N-hexylamine (b.p.--90°-95° C./0.6 mmHg).

1. distillationThe hexylamine in excess was then distilled off under vacuum
2. dissolutionthe residue dissolved in 300 ml of ethyl ether
3. washwashed with 200 ml of 0.5N sodium hydroxide
4. customevaporated to dryness
5. customthus yielding 75.5 g of a crude which
6. distillationby distillation under vacuum