Hydrogen chloride-ethyl acetate → HCID 67539344, compound

HRID 40022Notes

Reaction equation

HRID 40022 reaction equation
[O:1]1[C:10]2[CH:9]=[C:8]([CH2:11][NH:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[C:26]([C:33]6[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=6)[CH:27]=[C:28]([O:31][CH3:32])[CH:29]=5)[N:24]=[CH:23][C:22]4=[O:39])[CH2:15][CH2:14]3)[N:7]=[CH:6][C:5]=2[O:4][CH2:3][CH2:2]1.[ClH:40].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:40].[O:1]1[C:10]2[CH:9]=[C:8]([CH2:11][NH:12][CH:13]3[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][N:21]4[C:30]5[C:25](=[C:26]([C:33]6[CH:34]=[CH:35][N:36]=[CH:37][CH:38]=6)[CH:27]=[C:28]([O:31][CH3:32])[CH:29]=5)[N:24]=[CH:23][C:22]4=[O:39])[CH2:17][CH2:18]3)[N:7]=[CH:6][C:5]=2[O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593982931-(2-(4-((2,3-dihydro-1,4-dioxino[2,3-c]pyridin-7-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-5-(pyridin-4-yl)quinoxalin-2(1H)-one

Product 1

HCID 67539344HCID 67539344, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 2 mL of an ethyl acetate solution containing 134 mg of 1-(2-(4-((2,3-dihydro-1,4-dioxino[2,3-c]pyridin-7-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-5-(pyridin-4-yl)quinoxalin-2(1H)-one, 1.5 mL of 4 mol/L hydrogen chloride/ethyl acetate was added at room temperature, and the resulting solid was filtered to give 150 mg of 1-(2-(4-((2,3-dihydro-1,4-dioxino[2,3-c]pyridin-7-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-5-(pyridin-4-yl)quinoxalin-2(1H)-one hydrochloride as a pale yellow solid.

Workup

  1. additionwas added at room temperature
  2. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-c77350cf0ad64826a15eaafffc4b66f4
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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