反应详情

To 2 mL of an ethyl acetate solution containing 134 mg of 1-(2-(4-((2,3-dihydro-1,4-dioxino[2,3-c]pyridin-7-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-5-(pyridin-4-yl)quinoxalin-2(1H)-one, 1.5 mL of 4 mol/L hydrogen chloride/ethyl acetate was added at room temperature, and the resulting solid was filtered to give 150 mg of 1-(2-(4-((2,3-dihydro-1,4-dioxino[2,3-c]pyridin-7-yl)methylamino)piperidin-1-yl)ethyl)-7-methoxy-5-(pyridin-4-yl)quinoxalin-2(1H)-one hydrochloride as a pale yellow solid.

1. additionwas added at room temperature
2. filtrationthe resulting solid was filtered