反应详情

4.3 ml of trifluoromethanesulfonic anhydride were added under an inert gas atmosphere at 0° C., to a mixture of 3.0 g of 3,6-dimethyl-4-hydroxy-benzaldehyde and 20 ml of pyridine and the mixture was stirred for 3 hours at ambient temperature. Then the reaction medium was poured into ice-cooled water and after extraction with dichloromethane, and drying of the organic phase over magnesium sulfate and concentrated to dryness under reduced pressure, the residue was chromatographed on silica, eluting with a cyclohexane/ethyl acetate mixture (9/1) to obtain 4.11 g of the expected product.

1. additionThen the reaction medium was poured into ice-
2. extractionafter extraction with dichloromethane
3. dry with materialdrying of the organic phase over magnesium sulfate
4. concentrationconcentrated to dryness under reduced pressure
5. customthe residue was chromatographed on silica
6. washeluting with a cyclohexane/ethyl acetate mixture (9/1)