Sodium Hydroxide → HCID 11800280, compound

HRID 400306Notes

Reaction equation

HRID 400306 reaction equation
[CH2:1]([N:5]1[C:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[S:23]([NH:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])(=[O:25])=[O:24])=[CH:13][CH:12]=2)=[C:8]([C:34]([O:36]C)=[O:35])[C:7]([CH3:38])=[N:6]1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>CCO>[CH2:1]([N:5]1[C:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[S:23]([NH:26][C:27]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:28])(=[O:24])=[O:25])=[CH:15][CH:16]=2)=[C:8]([C:34]([OH:36])=[O:35])[C:7]([CH3:38])=[N:6]1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10530515HCID 10530515, compound

Product 1

HCID 11800280HCID 11800280, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of the compound obtained in example 51 (0.26 g, 0.5 mmol), 2N NaOH (2.5 mL) and EtOH (25 mL) was stirred at room temperature for 6 days. The solvent was removed and the residue taken up in EtOAc-H2O. The aqueous phase was acidified and extracted with EtOAc, dried and concentrated to afford the desired product as a white solid (0.1 g, 38%).

Workup

  1. customThe solvent was removed
  2. extractionextracted with EtOAc
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-fec15de00e114f479a28d896ea16e301
Source dataset
uspto-grants-1998_10
Patent number
US05827863

Reaction notes

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