Hydrochloric Acid → HCID 44246618, compound

HRID 400333Notes

Reaction equation

HRID 400333 reaction equation
[CH2:1]([O:8][C:9]1[N:17]=[CH:16][N:15]=[C:14]2[C:10]=1[N:11]=[CH:12][N:13]2[CH2:18][C:19]([O:21]C)=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[CH2:1]([O:8][C:9]1[N:17]=[CH:16][N:15]=[C:14]2[C:10]=1[N:11]=[CH:12][N:13]2[CH2:18][C:19]([OH:21])=[O:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59289995Methyl [6-(benzyloxy)-9H-purin-9-yl]acetate

Product 1

HCID 44246618HCID 44246618, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl (6-(Benzyloxy)purin-9-yl)acetate (2.10 g; 7,0 mmol) was dissolved in methanol (70 ml) and 0.1 M NaOH (85 ml) is added. After 15 min. the pH of the reaction mixture was lowered by addition of 0.1 M HCl (˜80 ml) to pH 3. The precipitate was separated from the mixture by filtration and washed with water and ether. Yield: 1.80 g (90.2%). 1H-NMR (DMSO-d6): 8.55 (1H, s); 8.37 (1H, s); 7.55-7.30 (5H, m); 5.64 (2H, s); 5.09 (2H, s).

Workup

  1. customThe precipitate was separated from the mixture by filtration
  2. washwashed with water and ether

Sources & evidence

ORD record
ord-8ee28a1c37a84c6db2d92915f38324e1
Source dataset
uspto-grants-2014_06
Patent number
US08741566B2

Reaction notes

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