Water → 4-Chloro-6-methoxypyrimidine

HRID 400420Notes

Reaction equation

HRID 400420 reaction equation
[CH3:1][O-:2].[Na+].[Cl:4][C:5]1[CH:10]=[C:9](Cl)[N:8]=[CH:7][N:6]=1.O>CO>[Cl:4][C:5]1[CH:10]=[C:9]([O:2][CH3:1])[N:8]=[CH:7][N:6]=1

Participants

5

Reactant 3

HCID 962WaterHCID 709434,6-DichloropyrimidineHCID 10942334Sodium Methoxide

Product 1

HCID 10515094-Chloro-6-methoxypyrimidineYield 101.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.1 g sodiummethanolate was added to 7.2 g 4,6-dichlorpyrimidine in 150 mL methanol at 0° C. The reaction was warmed to RT and stirred additional 3 h. Water and EtOAC were added and the layers were separated. The organic layer was dried and evaporated to give 7.1 g of the desired product.

Workup

  1. customthe layers were separated
  2. customThe organic layer was dried
  3. customevaporated

Sources & evidence

ORD record
ord-62ae386c7fd94610b67171771a086042
Source dataset
uspto-grants-2014_06
Patent number
US08741892B2

Reaction notes

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